President Barack Obama has arrived in Cuba for a historic visit to the island and talks with its communist leader.
He is the first sitting US president to visit since the 1959 revolution, which heralded decades of hostility.
“Looking forward to meeting and hearing directly from the Cuban people,” he tweeted on arrival.
Mr Obama will meet President Raul Castro, but not retired revolutionary leader Fidel Castro, and the pair will discuss trade and political reform.
The US president emerged smiling from Air Force One with First Lady Michelle and their daughters Sasha and Malia.
Holding umbrellas, the party walked in light drizzle along a red carpet to be greeted by Cuban Foreign Minister Bruno Rodriguez.
President Obama’s visit is the highpoint of a recent easing of ties, which included the opening of embassies last year.
But only hours before his arrival, protesters calling for the release of political prisoners were arrested in the capital, Havana.
Police took away dozens of demonstrators from the Ladies in White group, formed of political prisoners’ wives, from outside a church where they attempt to hold weekly protests.
Correspondents say the visit – the first by a sitting US president for 88 years – marks a huge turnaround in US-Cuban relations.
Two Cubans smile widely as they take part in a weekly rumba dance gathering in Havana, Cuba, Saturday, March 19
It is hard to overstate the significance of this trip because as recently as 18 months ago, the idea of a US president setting foot on Cuban soil would have been unthinkable, the BBC’s North America editor Jon Sopel says.
It represents the opening of a new chapter in the affairs of the two nations, our correspondent says.
Mr Obama and Raul Castro will sit together at a state dinner, there will be a joint news conference and they will discuss trade.
The White House has made it clear President Obama will meet political dissidents, whether the Cuban authorities like it or not. That is expected to include members of the Ladies in White group.
This visit does not mark a complete normalisation in relations, however.
The 54-year-old US economic embargo of Cuba is still in place and can only be lifted by a vote in Congress. Meanwhile, Cuba still complains about the occupation of the US naval base at Guantanamo Bay.
Nevertheless enormous strides have already been taken, our correspondent says.
Mr Obama and Mr Castro agreed in December 2014 to end decades of frozen relations that began when Cuba’s revolution overthrew a pro-US government.
Since 2014 there have been commercial deals on telecoms and a scheduled airline service, increased co-operation on law enforcement and environmental protection.
On Wednesday Mr Obama sent a letter on the first direct mail flight from the US to Cuba since the revolution.
And on Sunday, US hotel company Starwood become the first American firm to agree a deal with the Cuban authorities since 1959.
Although the US president is not scheduled to meet Fidel Castro, Cubans were reminded of their former veteran leader on Sunday as newspapers published pictures of him meeting Venezuela’s Nicolas Maduro.
Analysts suggested the release of the pictures underlines conflicting sentiments within the Communist Party over hosting Mr Obama.